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VOL. 1, ISSUE 1 (2025)
Anti-Inflammatory Effects of Catharanthus roseus: A Systematic Review of In vivo and In vitro Evidence
Authors
Eka Santi
Abstract
Eligible studies will include experimental
models of inflammation, such as carrageenan-induced paw edema,
lipopolysaccharide-stimulated macrophages, and cytokine expression assays. Data
extraction will focus on study design, plant preparation, dosage, experimental
models, outcome measures, and reported anti-inflammatory effects. The quality
of included studies will be assessed using standardized risk-of-bias tools
appropriate for in vivo and In vitro experiments. Preliminary
analysis suggests that C. roseus exerts significant anti-inflammatory effects
by modulating key pro-inflammatory mediators, including tumor necrosis
factor-alpha, interleukin-6, and nitric oxide, and by reducing oxidative stress
markers. These effects appear to be dose-dependent and vary with the type of
extract and experimental model used. The anticipated outcome of this systematic
review is to provide a rigorous synthesis of the current preclinical evidence,
identify gaps in the literature, and guide future pharmacological investigations
and potential therapeutic applications of C. roseus. Overall, the study aims to
contribute to the evidence-based understanding of C. roseus as a candidate
anti-inflammatory agent.
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Pages:27-31
How to cite this article:
Eka Santi "Anti-Inflammatory Effects of <i>Catharanthus roseus</i>: A Systematic Review of <i>In vivo</i> and <i>In vitro </i>Evidence". World Journal of Diabetes, Vol 1, Issue 1, 2025, Pages 27-31
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